[HTML][HTML] 3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1β interferes with mature IL-1β signaling
F Davaro, SD Forde, M Garfield, Z Jiang… - Journal of Biological …, 2014 - ASBMB
Multiple clinical trials have shown that the 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-
CoA) reductase inhibitors known as statins have anti-inflammatory effects. However, the
underlying molecular mechanism remains unclear. The proinflammatory cytokine interleukin-
1β (IL-1β) is synthesized as a non-active precursor. The 31-kDa pro-IL-1β is processed into
the 17-kDa active form by caspase-1-activating inflammasomes. Here, we report a novel
signaling pathway induced by statins, which leads to processing of pro-IL-1β into an …
CoA) reductase inhibitors known as statins have anti-inflammatory effects. However, the
underlying molecular mechanism remains unclear. The proinflammatory cytokine interleukin-
1β (IL-1β) is synthesized as a non-active precursor. The 31-kDa pro-IL-1β is processed into
the 17-kDa active form by caspase-1-activating inflammasomes. Here, we report a novel
signaling pathway induced by statins, which leads to processing of pro-IL-1β into an …
