Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel …
SR Lessin, M Duvic, J Guitart, AG Pandya… - JAMA …, 2013 - jamanetwork.com
Objective To evaluate the efficacy and safety of a novel mechlorethamine hydrochloride,
0.02%, gel in mycosis fungoides. Design Randomized, controlled, observer-blinded,
multicenter trial comparing mechlorethamine, 0.02%, gel with mechlorethamine, 0.02%,
compounded ointment. Mechlorethamine was applied once daily for up to 12 months. Tumor
response and adverse events were assessed every month between months 1 and 6 and
every 2 months between months 7 and 12. Serum drug levels were evaluated in a subset of …
0.02%, gel in mycosis fungoides. Design Randomized, controlled, observer-blinded,
multicenter trial comparing mechlorethamine, 0.02%, gel with mechlorethamine, 0.02%,
compounded ointment. Mechlorethamine was applied once daily for up to 12 months. Tumor
response and adverse events were assessed every month between months 1 and 6 and
every 2 months between months 7 and 12. Serum drug levels were evaluated in a subset of …
