How protozoan parasites evade the immune response

S Zambrano-Villa, D Rosales-Borjas, JC Carrero… - Trends in …, 2002 - cell.com
S Zambrano-Villa, D Rosales-Borjas, JC Carrero, L Ortiz-Ortiz
Trends in parasitology, 2002cell.com
Protozoan pathogens such as Plasmodium, Leishmania, Trypanosoma and Entamoeba are
responsible for several of the most widespread and lethal human diseases. Their successful
survival depends mainly on evading the host immune system by, for example, penetrating
and multiplying within cells, varying their surface antigens, eliminating their protein coat, and
modulating the host immune response. Immunosuppression is sometimes caused directly by
parasite products and sometimes involves antigenic mimicry, which often appears in …
Abstract
Protozoan pathogens such as Plasmodium, Leishmania, Trypanosoma and Entamoeba are responsible for several of the most widespread and lethal human diseases. Their successful survival depends mainly on evading the host immune system by, for example, penetrating and multiplying within cells, varying their surface antigens, eliminating their protein coat, and modulating the host immune response. Immunosuppression is sometimes caused directly by parasite products and sometimes involves antigenic mimicry, which often appears in association with parasitic diseases. However, one of the most sophisticated mechanisms of evasion is the selective activation of a subset of T helper cells.
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