A relevant experimental model for human bronchiolitis obliterans syndrome
S Atanasova, M Hirschburger, D Jonigk, M Obert… - The Journal of Heart and …, 2013 - Elsevier
Background The long-term success of human lung transplantation is limited by the
development of bronchiolitis obliterans syndrome. Acute rejection episodes and infections
are important risk factors and seem to play major pathogenic roles. We established a
relevant experimental model that mimics important aspects of human bronchiolitis obliterans
syndrome. Methods The Fischer 344-to-Lewis rat strain combination was used for orthotopic
left lung transplantation. Isogeneic transplantations were performed in the Lewis rat …
development of bronchiolitis obliterans syndrome. Acute rejection episodes and infections
are important risk factors and seem to play major pathogenic roles. We established a
relevant experimental model that mimics important aspects of human bronchiolitis obliterans
syndrome. Methods The Fischer 344-to-Lewis rat strain combination was used for orthotopic
left lung transplantation. Isogeneic transplantations were performed in the Lewis rat …
