[HTML][HTML] Bone marrow transplantation alters lung antigen-presenting cells to promote TH17 response and the development of pneumonitis and fibrosis following …
X Zhou, H Loomis-King, SJ Gurczynski, CA Wilke… - Mucosal …, 2016 - Elsevier
Hematopoietic stem cell transplantation (HSCT) efficacy is limited by numerous pulmonary
complications. We developed a model of syngeneic bone marrow transplantion (BMT)
followed by infection with murine gamma herpesvirus-68 that results in pneumonitis and
fibrosis and mimics human “noninfectious” HSCT complications. BMT mice experience
increased early lytic replication, but establish viral latency by 21 days post infection. CD4 T
cells in BMT mice are skewed toward interleukin (IL)-17A rather than interferon (IFN)-γ …
complications. We developed a model of syngeneic bone marrow transplantion (BMT)
followed by infection with murine gamma herpesvirus-68 that results in pneumonitis and
fibrosis and mimics human “noninfectious” HSCT complications. BMT mice experience
increased early lytic replication, but establish viral latency by 21 days post infection. CD4 T
cells in BMT mice are skewed toward interleukin (IL)-17A rather than interferon (IFN)-γ …
