ATP and adenosine are purines that play dual roles in cell metabolism and neuronal
signaling. Acting at the A1 receptor (A1R) subtype, adenosine acts directly on neurons to
inhibit excitability and is a powerful endogenous neuroprotective and anticonvulsant
molecule. Previous research showed an increase in ATP and other cell energy parameters
when an animal is administered a ketogenic diet, an established metabolic therapy to
reduce epileptic seizures, but the relationship among purines, neuronal excitability and the …