Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance
JM Moreno-Navarrete, G Blasco, J Puig… - International Journal of …, 2017 - nature.com
International Journal of Obesity, 2017•nature.com
Results: Circulating LBP concentration was associated with FA and L1 values of several
white matter regions both at baseline and follow-up. The associations remained significant
after controlling for age, BMI, fat mass and plasma high sensitivity C-reactive protein.
Importantly, the increase in LBP over time impacted negatively on FA and L1 values and on
DST performance. Conclusions: Circulating LBP associates with brain white matter integrity
and working memory/short-term verbal memory in both obese and non-obese subjects.
white matter regions both at baseline and follow-up. The associations remained significant
after controlling for age, BMI, fat mass and plasma high sensitivity C-reactive protein.
Importantly, the increase in LBP over time impacted negatively on FA and L1 values and on
DST performance. Conclusions: Circulating LBP associates with brain white matter integrity
and working memory/short-term verbal memory in both obese and non-obese subjects.
Results:
Circulating LBP concentration was associated with FA and L1 values of several white matter regions both at baseline and follow-up. The associations remained significant after controlling for age, BMI, fat mass and plasma high sensitivity C-reactive protein. Importantly, the increase in LBP over time impacted negatively on FA and L1 values and on DST performance.
Conclusions:
Circulating LBP associates with brain white matter integrity and working memory/short-term verbal memory in both obese and non-obese subjects.
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