[HTML][HTML] A soluble form of P selectin glycoprotein ligand 1 requires signaling by nuclear factor erythroid 2–related factor 2 to protect liver transplant endothelial cells …
C Zhang, Y Zhang, Y Liu, S Kageyama, F Gao… - American Journal of …, 2017 - Elsevier
Liver endothelial cell (LEC) damage is essential in the pathogenesis of ischemia–
reperfusion injury (IRI) in transplant recipients. We analyzed the mechanism of LEC
resistance against IRI by using a novel recombinant soluble form of P selectin glycoprotein
ligand 1, tandem P selectin glycoprotein ligand immunoglobulin (TSGL-Ig), in a mouse
model of hepatic cold preservation (4° C in University of Wisconsin solution for 20 h) and
syngeneic orthotopic liver transplantation (OLT). Unlike controls, TSGL-Ig protected …
reperfusion injury (IRI) in transplant recipients. We analyzed the mechanism of LEC
resistance against IRI by using a novel recombinant soluble form of P selectin glycoprotein
ligand 1, tandem P selectin glycoprotein ligand immunoglobulin (TSGL-Ig), in a mouse
model of hepatic cold preservation (4° C in University of Wisconsin solution for 20 h) and
syngeneic orthotopic liver transplantation (OLT). Unlike controls, TSGL-Ig protected …
