[HTML][HTML] Glutamine and norepinephrine in follicular fluid synergistically enhance the antioxidant capacity of human granulosa cells and the outcome of IVF-ET

L Wang, C Zhou, J Sun, Q Zhang, D Lai - Scientific Reports, 2022 - nature.com
An increasing number of studies demonstrate that changes in neurotransmitters metabolic
levels in follicular fluid are directly related to oocyte maturation, fertilization, the quality of
embryo and pregnancy rates. However, the relationship between the intra-follicular
neurotransmitters and the function of granulosa cells (GCs), and the outcome of in vitro
fertilization-embryo transfer (IVF-ET) is not clear. Human follicular fluid and cumulus GCs
were harvested from large follicles obtained from patients undergoing IVF. Neurotransmitters …

Glutamine and norepinephrine in follicular fluid synergistically affect the antioxidant capacity of human granulosa cells and the outcome of IVF-ET

L Wang, C Zhou, J Sun, Q Zhang, D Lai - 2022 - researchsquare.com
Background: An increasing number of studies have demonstrated that changes in metabolic
levels in follicular fluid are directly related to oocyte maturation, fertilization, the quality of
embryo and pregnancy rates. However, whether the intra-follicular neurotransmitters affect
the function of granulosa cells and the outcome of in vitro fertilization and embryo transfer
(IVF-ET) is not clear. Methods: Human follicular fluid and cumulus granulosa cells (GCs)
were harvested from large follicles obtained from 27 patients undergoing IVF …