Fucosylation in cancer biology and its clinical applications

M Shan, D Yang, H Dou, L Zhang - Progress in molecular biology and …, 2019 - Elsevier
Fucosylation is the process of transferring fucose from GDP-fucose to their substrates, which
includes certain proteins, N-and O-linked glycans in glycoprotein or glycolipids, by
fucosyltransferases in all mammalian cells. Fucosylated glycans play vital role in selectin-
mediated leukocyte extravasation, lymphocyte homing, and pathogen–host interactions,
whereas fucosylated proteins are essential for signaling transduction in numerous ontogenic
events. Aberrant fucosylation due to the availability of high energy donor GDP-fucose …