Medial thinning and atherosclerosis—evidence for involvement of a local inflammatory effect

AC van der Wal, AE Becker, PK Das - Atherosclerosis, 1993 - Elsevier
Medial attenuation in relation to atherosclerotic plaques is poorly understood. We
investigated the potential role of a local inflammatory response. Segments of carotid artery
and descending aorta were studied. The samples were grossly normal (n= 10), presented
circumscribed atherosclerotic plaques (n= 19) or confluent atherosclerotic lesions (n= 8).
Tissues were fixed in formalin or snap frozen in liquid nitrogen. Sections were stained with
conventional staining methods and immunohistochemically (smooth muscle cells …